Questions and answersThe winning combination
Does the preconstituted association of imidacloprid and permethrin work better than the two compounds applied on their own?Yes, each active substance acts by contact, exerting its own action on the nerve cells of the parasites at different sites. Do imidacloprid and permethrin act on ectoparasites in the same way?Imidacloprid and permethrin belong to different chemical classes and act on different nerve structures of the ectoparasites: imidacloprid induces post-synaptic agonist blockade of the acetylcholine receptors, permethrin keeps open the sodium channels along the axons of the insects, producing an increase in the intensity of the normal nerve stimuli. How can one explain the difference in efficacy between fipronil and permethrin against ticks?Fipronil and permethrin act on different nerve structures; furthermore, the association of imidacloprid and permethrin has been shown to be more active on ticks than permethrin used on its own. The pyrethroids in general, and permethrin in particular, because of peculiar chemical characteristics and a low melting point (which allows a vapour effect), express a powerful repellent effect which keeps arthropods away. Is there a certain degree of resistance to permethrin in populations of parasites?Insects develop resistance to all insecticidal products over time. Even with pyrethroids there are some reports of lesser efficacy in the literature. However, these active substances are still among the most efficacious. The association of imidacloprid and permethrin in advantix also means that efficacy against mosquitoes and ticks is high and prolonged, as various studies have shown. |
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